TREATMENT AND PREVENTIVE APPROACHES TO PSORIASIS PATIENTS AFTER
CORONAVIRUS INFECTION

About the author:	Kutasevych Ya.F., Oliinyk I.O., Mashtakova I.O., Dzhoraieva S.K., 
Kondakova G.K., Vitkovska M.O., Yereshchenko O.O.	
Heading	CLINICAL OBSERVATIONS	
Type of article	Scientific Article	
Annotation	The results of preliminary observations indicate that the SARS-COV-2 virus can also 
affect the skin and affect the course of chronic diseases, including dermatoses. The 
cause and pathogenesis of skin manifestations have not yet been established and are
 under study, but they are most likely caused by infectious and allergic damage to 
blood vessels, as well as a high level of pro-inflammatory cytokines.
The subject is to  increase the effectiveness of the therapy of patients with psoriasis 
after suffering from the coronavirus disease by using drugs that affect the state of the 
endothelium of blood vessels and the blood coagulation system.
Materials and methods. 69 patients with psoriasis associated with COVID-19 
infection were under observation. The patients were divided into two clinical and
 therapeutic groups, which were representative in terms of age, sex, and severity of
 the disease: The first experimental group (36 patients) in complex treatment received 
drugs that had an effect on the normalization of endothelial dysfunction and the blood
 coagulation system. Patients of the II group (33 persons) received treatment 
according to the protocols. The control group consisted of 20 practically healthy 
persons, representative in terms of age and sex. Control of the treatment was carried 
out on the basis of clinical and laboratory data. Subjective and objective signs of the 
disease were evaluated, clinical and biochemical indicators were determined, 
including a general blood test, the state of the coagulation system using modern 
standardized laboratory tests.The degree of inflammatory reaction was assessed by
 the level of C-reactive protein and IL-6. Statistical processing of data was carried out 
using methods of variational statistics. Significance of differences was assessed using 
Student’s test for independent samples.
The results. When using drugs that had an effect on the normalization of endothelial 
dysfunction and the blood coagulation system,in the complex treatment of patients 
of the 1st group, a significant improvement in the general condition was noted, a 
decrease in the subjective symptoms of the disease: itching, dryness, soreness in the 
foci of inflammation, which decreased 3–4 days earlier, than in patients from the 
comparison group who received traditional therapy. Clinical remission in patients of
 the I group occurred in (22.3± 2.7) days, while in patients in the II group – in 
(29.2 ± 3.5) days, that is, 6.9 days earlier (p < 0, 05). The use of the proposed
 treatment-prophylactic approach improved the parameters of the blood coagulation
 system in patients with psoriasis who suffered a coronavirus infection, which was 
manifested by the normalization of AChT, PTI, fibrinogen content and a significant 
decrease in D-dimer,which indicates a probable reduction in the risk of thrombotic 
complications. At the same time, there was a significant decrease in inflammation
 indicators – PSA and IL-6.
Conclusions. The use of the proposed treatment-prophylactic approach contributed 
to an earlier onset of clinical remission: the subjective and objective signs of the 
disease stopped almost 7 days earlier than in patients treated only by traditional 
methods, normalization of indicators of the state of the coagulation system, 
endothelial dysfunction, which prevented development of complicationsfrom the 
cardiovascular system.	
Tags	psoriasis, COVID-19, coagulation system, interleukin-6, C-reactive protein, treatment	
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Publication of the article	«DERMATOLOGY AND VENEREOLOGY» №4(102), 2023 year, 12-16 pages,
	
DOI	10.33743/2308-1066-2023-4-12-16