MANAGEMENT­OF­SEXUALLY­TRANSMITTED­INFECTIONS­TAKING­INTO­ACCOUNTTHE­MICROBIOCENOSE­OF­THE­UROGENEITRAL­TRACT

About the author:	Bondarenko G.M., Unuchko S.V., Dzhoraieva S.K. , Fedorich P.V.,
Gubenko T.V., Namli I.Ye.	
Heading	CLINICAL OBSERVATIONS	
Type of article	Scientific Article	
Annotation	An urgent problem of modern medicine is the significant spread of sexually 
transmitted infections (STD). Mixed infection leads to a change in the biological 
properties of pathogens, increases their virulence, and thereby aggravates the 
pathological process, causes resistance to therapy, contributes to the occurrence of
relapses and complications after treatment, and requires additional diagnostic and 
therapeutic measures.
The purpose of the study: – study of the microbiocenosis of the genitourinary tract in 
patients with signs of STD and determination of the sensitivity of clinically significant 
microorganisms to antibacterial drugs of various chemical groups.
Materials and methods. The Research results on the presence of STD pathogens was 
carried out in accordance with documents regulated by the Ministry of Health of 
Ukraine, as well as the instructions of manufacturers of diagnostic test systems. The 
quality control of the method of determining the sensitivity of microorganisms to 
antibiotics, the quality of the reagents used (nutrient media and disks with antibiotics) 
was carried out using the control strains of the American Collection of Type Cultures 
(ATSC): E.soli АТСС 25922, S. aureus АТСС 25923, P. aeruginosa ATCC27853, 
E. faecalis ATCC29212.
Research results: 351 patients with signs of an inflammatory process of the urogenital 
tract, tested for the presence of STD, participated in the study. It was established that 
trichomonas infection in the population of reproductive age is dominant and occurs 
more often in women – 63.5% and 49.5% in men. 18 laboratory strains of 
staphylococci were isolated from patients with inflammatory diseases of the urogenital 
tract (13 strains from men and 5 strains from S. haemolyticus, S. epidermidis (44.4% 
and 16.7%, respectively). Representatives of the family were also found in the 
structure of microbiocinoses Enterobacteriaceae (21 strains – 9 from men and
12 from women). When assigning treatment to patients, it is necessary to take into 
account the presence of conditionally pathogenic microflora, which occurs in 18.0% of 
cases as an associate of trichomonas infection in women and in 14.0% of men.
Conclusion. For patients with a mixed urogenital infection, it is advisable to prescribe
antibacterial therapy taking into account the data of bacteriological research and the 
detection of levels of resistance to antibacterial drugs of different chemical groups of
 clinically significant microorganisms.	
Tags	sexually transmitted infections, urogenital chlamydiosis, urogenital trichomoniasis, 
mixed urogenital infection, microbiocenosis of the genitourinary tract	
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Publication of the article	«DERMATOLOGY AND VENEREOLOGY» №4(102), 2023 year, 7-11 pages,
	
DOI	10.33743/2308-1066-2023-4-7-11