COMPARATIVE ASSESSMENT OF THE SENSITIVITY OF CAUSES OF WOUND INFECTIONS TO TOPICAL ANTIBACTERIAL DRUGS

About the author:	Kutasevych Ya.F., Dzhoraieva S.K., Lyapunov M.O., Khoroshun E.M., 
Birukov M.S.,Kupriyanchuk V.V., Shipilov S.A., Mashtakova I.O., 
Goncharenko V.V., Ivantsova O.K.	
Heading	ORIGINAL RESEARCHES	
Type of article	Scientific Article	
Annotation	The problems of treating victims with gunshot wounds are determined by the issue of
 prevention and treatment of purulent complications, because wounds received during
 hostilities are a priori infected, and the most dangerous complication of wounds is
the development of purulent infection.
The purpose of the research is to study the peculiarities of the microbial landscape 
of combat wounds and the antimicrobial activity of certain drugs in relation to 
extensively resistant and polyresistant microbial agents in order to develop algorithms
 in external therapy within the framework of complex treatment of these injuries
Materials and methods. The data of microbiological studies of 32 victims with gunshot
 wounds were used in the work.
Research results: Based on the results of monitoring the causative agents of 
purulent-inflammatory complications of wound injuries,a range of leading types of 
microorganisms was established: K. pneumoniae E. faecalis, S. haemolyticus, 
P. aeruginosa, E. coli. The isolation of flora resistant to most antibiotics from wounds 
dictates the need to change the strategy of infection control with strengthening 
measures to prevent nosocomial transmission and should be taken into account in the
 process of prescribing antibiotic therapy.
Conclusion. The obtained results of the pilot study demonstrate the microbiological 
effectiveness of dioxidin, partially mupirocin and fusidin, which can be used in the 
complex treatment of microbial complications of wound injuries and the development 
of optimal tactics for providing medical care and treatment of the wounded, and can 
also serve as a basis for the development of a method of complex treatment for 
certain phases wound process, which allow simultaneous influence on several factors 
of pathogenesis.	
Tags	microflora of gunshot wounds, sensitivity of microbial agents to antibiotics, 
topical antibacterial agents	
Bibliography	1. Voenno-polova khirurgiya: prakt.i navch.posib dlya viyskovukn likariv ta 
likariv systemy okhorony zdorovia [Military and field surgery: pract. i navch. 
posib. for viysk. doctors and doctors of the health care system of Ukraine] 
/ za red. Ya. L. Zarutchkogo, V. Ya Biligo; M-vo oborony  Ukrainy, MOZ 
Ukrainy. Kyiv. Feniks. 2018. 544 p.
2. Dysko-difuziynuy metod vuznashennya chutluvosti do antibiotukiv 
[Disk-diffusion method for determining sensitivity to antibiotics]. EUCAST. 
Version 10.0 (January 2022). www.eucast.org
3. Kutasevych YaF, Dzhoraieva SK, Oliynyk OI et al. Zovnischnya 
antibakterialna terapiya: sychasni moglyvosti likuvannya [Modern Antibacterial 
Therapy: Current Opportunity]. Dermatologiya & venerologiya. 2019; 3(85): 
24–30.
4.Schtanuk EA., Minyrhin VV., Lyapunov NA. et al Izushenie antimicrobnoy 
aktivnosti mazey, soderzhashchirh dioksidin, na standartnykh schtammarh 
vozbuditeley ranevoy infektchii [Study of the antimicrobial activity of ointments 
containing dioxidine on standard strains of the main causative agents of wound infection] 
Universum: meditchina I farmokologiya. 2014; 5 (6), razdel 43: Khimioterapiya 
i antibiotiki
5. Kovalchuk VP, Kondratuk BM. Dynamika vydovogo skladu mikroflory
 boyovyrh (bognepalnyrh ta minno-vubukhovykh) ran kintchivok, oderzhanykh 
pid chas antyterorestychnoy operatchii na skhodi Ukrayiny u 2014 rotchi 
[Dynamics of the species composition of the microflora of combat (fire and 
mine-explosive) wounds of the limbs, received during the anti-terrorist operation
 in the east of Ukraine in 2014]. Khirurgiya Ukrainy. 2016; 2: 13–18.
6. Zheliba MD, Verba AV, Bogusch GL et al. Microbiologichni aspekty ranovoi 
infektchii u poterpilykh vnaslidok boyovyrh diy ta ii kompleksne likuvannya z 
zastosuvannyam vacuum-terapii [Microbiological aspects of wound infection in 
combat victims and its complex treatment using vacuum therapy]. Suchasni 
medichni tekhnologii. 2019; 3: 50–55.
7. Parkhomenko KU, Tchivenko OI, Schmorgun VV et al. Suchsnuy poglyad ta 
perspektyvy zastosuvannya vacuum-terapii u kompleksnomu likuvanni 
vognepalnykh ran (oglyad literatury) [Modern view and prospects of using 
vacuum therapii in the complex treatment of gunshot wounds (literature review)]. Visnyk Kharkovskogo 
Natchionalnogo universytety imeni V. N. Karazina. Seriya «Medytchina». 2023;
 46: 89–100.
8. Fomin NS, Fomina VM, Kondratuk BM et al. Kharakterystyka efektyvnosti 
likuvannya vognepalnykh poranen z vykorystznnyam vacu- therapii 
[Characteristics of the effectiveness of treatmentof gunshot wounds using vac
therapy] Visnyk Vinnytchkogo Natchionalnogo mtdychnogo universytety. 2020; 
24 (1): 106–109.
9. A Guide to Utilization of the Microbiology Laboratory for Diagnosis of 
Infectious Diseases: 2018 Recommendations by the Infectious Diseases Society 
of America (IDSA) and the American Society for Microbiology (ASM)a. Clinical 
Infectious Diseases. 2018: 104
10. Magiorakos AP, Srinivasan A, Careyet RB et al. Multidrug-resistant, 
extensively drug-resistant and pandrug-resistant bacteria: an international expert 
proposal for interim standard definitions for acquired resistance. Clin. Microbiol. 
Infect. 2012; 18: 268–281.
11. Kunze KN, Hamid KS, Lee S et al. Negative-pressure wound therapy in 
foot and ankle surgery. Foot Amp Ankle Int. 2020; 41(3): 364–72.
12. Horch RE, Ludolph I, Müller-Seubert W et al Topical negative-pressure 
wound therapy: emerging devices and techniques. Expert Rev Med Devices. 
2020; 17(2): 139–48
  	
Publication of the article	«DERMATOLOGY AND VENEREOLOGY» №2(100), 2023 year, 7-10 pages,
	
DOI	10.33743/2308-1066-2023-2-7-10