THE PLACE OF ANTIMICROBIAL TOPIC THERAPY IN DERMATOLOGY

About the author:	Kaliuzhna L.D	
Heading	CLINICAL OBSERVATIONS	
Type of article	Scientific Article	
Annotation	The cutaneous flora is relatively simple compared to the diverse community of 
microorganisms that inhabits the mouth, digestive tract and vagina. The ecology of
 particular areas of the skin is determined by the availability of moisture, the level of 
sebaceous lipids. Microbial agents, especially Staphilococcus aureus, colonize over 
90% of atopic dermatitis skin lesions. Presented our approach to topical treatment of 
skin diseases with superficial pyoderma, chronical diseases of skin with microbial 
disbalance by the ointment Ilon Classic.	
Tags	microbiome, atopic dermatitis, pyoderma, topic treatment, ointment Ilon Classic	
Bibliography	 1. Hajjar E. R., Cafiero A. C., Hanlon J. T. Polypharmacy in elderly patients. 
Aamerican Journ Geriatr Pharmacotherapy. 2007; 5; 4: 341–351.
2. Кim H. Y. Statistical notes for clinical researchers: Risk difference, risk ratio,
 and odds ratio. Restor. Dent. Endod. 2017. Feb;42(1): 72–76. 
DOI:10.5395/rde.2017.42.1.72.
3. Mockenhaupt M. Severe drug induced skin reactions: clinical pattern, 
diagnostics and therapy. JDDG, 2008; 7: 142–162.
4. Naresawa G. Drug-induced skin reactions. Japan Med Assoc Journ. 2006; 
49; 2: 47–48.
5. Feudtner C., Dai D., Hoxem K. R., Luan X., Mrtjian T. A. Prevalence of
 polypharmacy exposure among hospitalized children in the United States. Arch
 Pediatr Adolesc Med. 2012; 1(166): 9–16.
6. Viktil K. K., Blix H. S., Moger T. A., Reikvam A. Polypharmacy as 
commonly defined is indication of limited value in the assessment of 
drug-related problems. British J of Clinical Pharmacology. 2006, 63; 2: 187–195.
7. Reider F., Pranab K., Mukherjee D. Skin microbiome in atopic dermatitis:
 new insighys from clinical trials. JEADV. 2023; 4: 649–650.
8. Roujeau J. C. Clinical heterogenaty of drug hypersensitivity. Toxicology. 
2005; 209: 123–129.
9. Sistrom C. L., Garvan C. W. Proportions, odds, and risk. Radiology. 2004; 
230 (1): 12–9. PMID14695382. DOI: 10.1148/radiol.2301031028.
10. Rauer L., Reiger M., Bhattecharyya M., Brunner P., Kruger S. Skin 
microbiome and its assotiation with hoestal cofactors in determining atopic 
dermatitis severity. JEADV 2023; 37: 772–782.
11. Paller A., Kong H., Seed P., Naik S., Schaschmidt T.et al. The 
microbiome in patients with atopic dermatitis. J Allergy Clin Immunol 2019; 
143(1): 26–35.
12. Valeyrie-Allanore L., Sassdas B., Roujeau J. C. Drug-induced skin, nail 
and hair disorders. Acis Data Information BV, 2007; 30(11): 1012–1028.	
Publication of the article	«DERMATOLOGY AND VENEREOLOGY» №2(100), 2023 year, 19-22 pages,
	
DOI	10.33743/2308-1066-2023-2-19-22