SOME FEATURES OF CYTOKINE STATUS IN PATIENTS WITH PSORIASIS  

About the author:	
Kutasevych Ya.F., Kondakova G. K., Dzhoraeva S. K., Sokol O. A., Shevchenko Z. M.	
Heading	ORIGINAL RESEARCHES	
Type of article	Scientific Article	
Annotation	The purpose of the study is to evaluate the content of IL‑7, –4 and –17A in the blood
 of patients with psoriasis, depending on the severity of the disease.
Materials and methods. A group of patients was examined, which included47 patients 
with vulgar psoriasis; 10 patients with arthropathic psoriasis, as well as a control 
group of15 conditionally healthy individuals. The content of interleukin –4, –7, –17A was deter‑
mined in blood serum by the immunoenzymatic method.
Results and conclusions. In patients with a severe course of psoriasis
(arthropathic psoriasis), pathological activation of hereditary and acquired(Th1- and 
Th17-types) immunity is observed, there is a dysregulation of the synthesis of 
Pro-inflammatory(IL-17) and anti-inflammatory(IL-4) cytokines. Detection of 
disturbances in the levels of mediators of the immune response, which are involved
in the formation of immune inflammation, in particular cytokines, in patients with 
psoriasis can serve as an additional test for predicting the clinical course of this 
dermatosis.	
Tags	psoriasis, arthropathic psoriasis, interleukins	
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Publication of the article	«DERMATOLOGY AND VENEREOLOGY» №1(99), 2023 year, 11-13 pages,
	
DOI	10.33743/2308-1066-2023-1-11-13