EVALUATION OF THE EFFICIENCY OF THE USE OF UVB THERAPY AS PART 
OF THE COMPLEX TREATMENT OF PATIENTS WITH ATOPIC DERMATITIS TAKING 
INTO ACCOUNT THE STATE OF SKIN MICROBIOCENOSIS 

About the author:	
Kutasevych Ya. F., Ziuban I. V., Dzhoraeva S. K.	
Heading	CLINICAL OBSERVATIONS	
Type of article	Scientific Article	
Annotation	Atopic dermatitis(AD) is a hereditary disease, the degree of clinical manifestations of
 which largely depends on the influence of environmental factors and the body’s 
resistance. The modern pathogenetic model of AD can be represented as a chain, 
the genetic links of which are considered to be: a set of predisposition genes, a 
reduced skin barrier function, a violation of innate immunity, which are joined by 
external factors and features of the adaptive immune response. The most significant 
genetically determined disorders in this disease are changes in the immune system 
and skin barrier, the dysfunction of which is a favorable background for
the development of AD. The second group of factors that influence the development 
of the disease is the triggers of the external environment: various chemical substances, food and medicinal irritants, infectious agents, etc.
Bacteriological research data indicate high rates of colonization density of lesions 
and conditionally intact skin areas of AD patients with moderately severe and severe 
severity[(6.5±0.2) lg CFU/cm2 and(6.3±0.1) lg CFU/cm2 and(6.9±0.2) lg CFU/cm2
and(6.8±0.2) lg CFU/cm2, respectively, against4.1±0.1 lg CFU/cm2on the skin of 
healthy persons, p ≤0.05]. When using narrow‑spectrum UVB therapy as part of
 complex treatment of severe forms of AD, regression of clinical signs of pyococcal 
infection was noted in72.2% of people. Clinical remission was achieved in 27.7% of 
patients, significant improvement in 55.5%, improvement in16.7%.	
Tags	atopic dermatitis, UVB therapy, skin microbiocenosis, complex therapy	
Bibliography	1. Ishcheikin KIe. Suchasnyi stan problemy zakhvoriuvanosti na spravzhniu 
ekzemu: pytannia etiolohii ta patohenezu [The current state of the problem of 
the incidence of true eczema: questions of etiology and pathogenesis]. Ukr. 
zhurn. dermatolohii, venerolohii, kosmetolohii. 2006; 3: 6–8.
2. Korotkiy NG, Belmer SV, Fabrika NP et al. K voprosu o patogeneze 
atopicheskogo dermatita [To the question of the pathogenesis of atopic 
dermatitis]. Vestn. postdiplomnogo med. obrazovaniya. 1999; 2: 12–13.
3. Kalyuzhnaya LD, Reznikova AA. Hronicheskiy zud, kak dermatologicheskiy 
sindrom [Chronic itching, like a dermatological syndrome]. Dermatolog. 2016; 1: 
46–49.
4. Suharev AV, Gutka VO, Patrushev AV et al. Kombinirovannaya naruzhnaya 
terapiya atopicheskogo dermatita, oslozhnennogo vtorichnoy infektsiey 
[Combined external therapy of atopic dermatitis complicated by secondary 
infection]. Vestnik dermatologii i venerologii. 2012; 5: 113–118.
5. Tihomirov TA, Fedorova NI, Korotkiy VN et al. Mikrobiologicheskie 
osobennosti vospalitelnogo protsessa v razlichnyih ekotopah u detey, 
stradayuschih atopicheskim dermatitom [Microbiological features of the 
inflammatory process in different ecotopes in children suffering from atopic 
dermatitis]. Klinicheskaya dermatologiya i venerologiya. 2016; 15(3): 43–47.
6. Batyirshina SV, Haertdinova LA, Halilova RG, Sabyinina EE. Mikrobiotsenoz 
kozhi u bolnyih atopicheskim dermatitom i ego korrektsiya [Skin microbiocenosis 
in patients with atopic dermatitis and its correction]. Prakticheskaya meditsina.
 2013; 1–4 (73): 33–37.
7. Murzina EO. Osoblyvosti mikrobioty shkiry ditei khvorykh na atopichnyi 
dermatyt [Features of the skin microbiota of children with atopic dermatitis]. 
Zbirnyk tsentru naukovykh publikatsii «Veles» za materialamy IV mizhnarodnoi 
naukovo‑praktychnoi konferentsii: «Vesniani naukovi chytannia», m. Kyiv: 
zbirnyk statei (riven standartu, akademichnyi riven). K.: Tsentr naukovykh 
publikatsii; 2019. 132 p.
8. Popov IV. Osobennosti mikrobiotsenoza kozhi pri atopicheskom dermatite 
[Features of skin microbiocenosis in atopic dermatitis]. Vestnik poslediplomnogo 
meditsinskogo obrazovaniya. 2014; 2: 58–62.
9. Reznichenko YuH, Pantiushenko LI, Reznichenko NIu. Khronichni alerhichni 
zakhvoriuvannia shkiry: suchasni uiavlennia pro etiopatohenez ta pidkhody do 
vyboru optymalnoi terapii [Chronic allergic skin diseases: modern concepts of etiopathogenesis and approaches to choosing optimal therapy]. Dermatovenerolohyia. Kosmetolohyia. 
Seksopatolohyia. 2012; 1–4: 247–254.
10. Grice EA, Kong HH, Renaud G et al. A diversity profile of the human skin 
microbiota. Genome research. 2008; 18(7): 1043–1050.
11. Sybilski AJ, Raciborski F, Lipiec A et al. Atopic dermatitis is a serious 
health problem in Poland. Epidemiology studies based on the ECAP study.
 Postepy Dermatol Alergol. 2015; 32(1): 1–10.
12. Kaliner M, Shelhamer JH, Davis PB et al. Autonomic nervus system 
abnormalities and allergy. Ann. Intern. Med. 1982; 96(3): 349–357.
13. Chen YE, Fischbach MA, Belkaid Y. Skin microbiota‑host interactions.
 Nature. 2018; 553 (7689): 427–436.
14. Jo JH, Deming C, Kennedy EA et al. Diverse human skin fungal 
communities in children converge in adulthood. J Invest Dermatol. 2016; 136:
 2356–2363.
15. Kong HH, Segre JA. The molecular revolution in cutaneous biology:
 investigating the skin microbiome. J. Invest. Dermatol. 2017; 137: 119–122.
16. Oh J, Conlan S, Polley EC et al. Shifts in human skin and nares 
microbiota of healthy children and adults. Genome Med. 2012; 4(10): 77.
17. Drucker AM, Wang AR, Li W‑Q et al. The Burden of Atopic Dermatitis:
Summary of a Report for the National Eczema Association. Journal of 
Investigative Dermatology. 2017; 137(1): 26–30.	
Publication of the article	«DERMATOLOGY AND VENEREOLOGY» №1(99), 2023 year, 14-19 pages,
	
DOI	10.33743/2308-1066-2023-1-14-19