STUDY OF ANTIBACTERIAL ACTIVITY OF OINTMENT WITH MUPIROCIN ON POLYRESISTENT CLINICAL STRAINS S. AUREUS, ISOLATED FROM PATIENTS WITH DISSEMINATED DERMATOSIS

About the author:	
Ya.F.Kutasevych, S.K.Dzhoraeva, O.I.Oliinyk, V.V.Goncharenko, 
N.V.Sobol, O.V.Shchogoleva, О.K.Ivantsova, A.R.Babuta, 
O.V.Pugachova
	
Heading	original research	
Type of article	Scientific Article	
Annotation	Disseminated dermatoses are characterized by frequent recurrence and are 
complicated by the accession of asecondary infection, often resistant to 
traditional antibacterial therapy.  The development of a topical drug that would
not be used systematically is  relevant today . 
The objective of the work:study of the antibacterial activity of  mupirocin
Ointment on  multidrug –resistant clinical strains of  S. aureus ,  isolated 
from patients with disseminated dermatoses.
Materials and methods.142 strains of S. aureus extracted from the affected 
areas of the skin of patients with disseminated  dermatoses were studied 
to determine the spectrum of sensitivity to antibacterial drugs. The method 
of diffusion into agar (method of  wells) was used to determine the antibacterial 
action of the ointment with mupirocin for 49 strains of S. aureus.
Results and discussion.It was found that mupirocin actively inhibited the growth of both 
MRSA  and MSSA strains. Among the 49 strains studied, no mupirocin resistant 
was found.
Conclusions. Ointment Bactopic with mupirocin is highly effective on clinical 
strains of S. aureus (including MRSA strains), wich  allows us to recommend 
it as an external therapy for microbial complications of disseminated 
dermatoses
.
	
Tags	clinical strains S. aureus, antibiotic resistance, external therapy, antibacterial 
therapy, mupirocin.
	
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Publication of the article	«DERMATOLOGY AND VENEREOLOGY» №1(91), 2021 year, 23-29 pages,
 index UDK 616.5–002.3–085	
DOI	DOI: 10.33743/2308-1066-2021-1-23-29