Title: CLINICAL AND DIAGNOSTIC PARALLELS OF POSTACNE MANIFESTATIONS
Author: Кондакова

SYNDROMOLOGICAL ASPECTS OF ROSACEA
About the author: | Sarayreh Anas Atalla Salem
Heading | ORIGINAL RESEARCHES
Type of article | Scientific Article

Annotation

The objective: to clarify the clinical syndromological manifestations of the skin and other body systems in women of reproductive age,patients with rosacea.
Materials and methods: clinical and laboratory examination of 52 women of reproductive age (from 18 to 35 years old), patients withrosacea. All patients consulted with a gynecologist, endocrinologist, neuropathologist.
Results and its discussion. A clear connection was found between the exacerbation of the course of dermatosis and disordersof the hypothalamic-pituitary-gonadal system in 59.6% of the examined women with rosacea, in particular, with menstrual irregularities in 15 of them (40.4%). These changes were mainly of a syndromic nature, and on the skin manifested mainly in the form of hirsutism, hyperpigmentation, atrophic striae, follicular hyperkeratosis, male alopecia. Separate skin manifestations typical of rosacea havea need to differentiate also with more than 20 other syndromes, in which there is a rash or cosmetic changes on the skin, dysendocrinia or vegetative-vascular disorders. Both for rosacea and for syndromes with rosacea-like changes, peptide signaling molecules of various classes (neuropeptides, prostaglandins, kinins, etc.) play an important role in pathogenesis, and the identification of changes in the content of these biologically active compounds in patients requires an adjustment to the complex therapy of patients.
Conclusions. In women with rosacea, the current features of the course of the disease are its appearance at an earlier age and the combination of dermatosis with certain syndromes (mainly associated with disorders of the hypothalamic-pituitary-gonadal system), which requires further study of the role of peptide signaling compounds in the pathogenesis of dermatosis as modulators of it regulatory activities and factors that may determine the clinical signs of the disease and rosacea-like manifestations in various syndromes.

Tags | rosacea, women of reproductive age, syndromes

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Publication of the article

«DERMATOLOGY AND VENEREOLOGY» №3(89), 2020 year, 16-20 pages,
 index UDK 616.5–007–036.17

DOI | 0.33743/2308-1066-2020-3-16-20