Estimation of efficiency of integrated treatment of patients with atopic dermatitis and eczema using phonophoresis with emollient
About the author:	Ya.F. Kutasevych, I.O. Oliinyk, O.M. Stuliy, I.V. Ziuban	
Heading	CLINICAL OBSERVATIONS	
Type of article	Research Article	
Annotation	The objective of the work is to evaluate the effectiveness of phonophoresis with emollient
 in the complex treatment of patients with atopic dermatitis and eczema.
Materials and methods. The study included 44 patients with atopic dermatitis and chronic
 eczema (21 men and 23 women,17 to 70 years old), who were divided into three study 
groups: I (experimental) – 15 people, II – 15; III – 14. And the group received 
phonophoresis with emollient of European production against the background of
 traditional therapy; II – on the background of traditional
therapy – applications with the specified emollient; III – only traditional therapy and other 
emollient. Patients were subjected to skin physiological parameters (moisture, elasticity,
 smoothness, pigmentation) on the Aramo TS using Skin XPPRO software.
Results. In all groups before treatment, the skin was characterized as dehydrated; 
elasticity was rated as weak; the index of smoothness indicated the changed relief of 
the skin with reduced index, folding and wrinkling; pigmentation was intensified. After 
treatment, the moisture of the epidermis improved to normal. The degree of hydration was
 restored in all groups. Elasticity in patients of group I increased to normal, group II 
remained in the zone of low elasticity, group III - the indicator did not change significantly.
 The relief of the skin after treatment in the patients of group I corresponded to the limits 
of norm; instead, in the II and III groups, the smoothness
tended to normalize, which corresponded to the uneven relief of the affected skin. 
After therapy, the degree of pigmentation in patients of group I decreased to normalization, and in patients of group II, although also significantly decreased, did not reach the limits of norm, in patients of 
group III – almost did not change.
Conclusions. The results of the study allow to reasonably prescribe the complex treatment 
of patients with atopic dermatitis and eczema using phonophoresis with emollient of the 
European manufacturer, which provides restoration of physiological parameters of the skin	
Tags	atopic dermatitis, eczema, physiological parameters of the skin, phonophoresis, emollient	
Bibliography	•	1.  Agafonov AS, Revyakina VA. Atopicheskiy dermatit u detey i infektsii, oslozhnyayuschie techenie bolezni [Atopic dermatitis in children and infections that complicate the course of the 
disease]. Lech. vrach. 2011;1:39–43.
2.  Belozorov  AP,  Zueva  MI.  Geneticheskie  aspektyi  dermatozov  allergicheskogo  geneza [Genetic aspects of allergic dermatoses]. Dermatolohiia ta venerolohiia. 2009;4(46):17–22.
3.  Olshamovskaya AO, Babkin AV, Grashin RA, et al. Biohimicheskie pokazateli krovi, korreliruyuschie s tyazhestyu techeniya atopicheskogo dermatita [Biochemical blood parameters correlating with the severity of atopic dermatitis]. Ros. zhurn. kozh. i ven. bolezney. 2012;1:35–37.
4.  Bolotna LA. Sukhist shkiry: prychyny ta mekhanizmy rozvytku, mozhlyvosti likuvalnoi kosmetyky [Dryness of the skin: causes and mechanisms of development, opportunities for therapeutic cosmetics]. Dermatolohiia ta venerolohiia. 2008;2(40):12–17.
5.  Volkoslavskaya VN. Nekotoryie storonyi deyatelnosti dermato-venerologicheskih uchrezhdeniy Ukrainyi za period 2000–2016 gg. [Some aspects of the activity of dermatovenereological 
institutions of Ukraine for the period 2000–2016]. Dermatolohiia ta venerolohiia. 2017;3(77):97.
6.  Kutasevych YF, Ischeykin KE, Ziuban IV, Manhusheva VYu. Differentsirovannyiy podhod k diagnostike i naruzhnoy terapii ekzemyi [Differentiated approach to the diagnosis and external 
therapy of eczema]. Dermatolohiia ta venerolohiia. 2018;1(79):50–55.
7.  Zueva MI, Ivanova NN. Nekotoryie geneticheskie aspektyi allergodermatozov na primere 
analiza mutatsiy R501X i 2282del4 gena FLG [Some genetic aspects of allergic dermatoses on the example of the analysis of mutations R501X and 2282del4 of the FLG gene]. Klin. immunologiya. 
Allergologiya. Infektologiya. 2012;1:104–106.
8.  Korostovtsev DS, Makarova IV, Revyakina VA, Gorlanov IA. Indeks SCORAD –  ob’ektivnyiy i  standartizovannyiy  metod  otsenki  porazheniya  kozhi  pri  atopicheskom  dermatite  [SCORAD 
Index –  an objective and standardized method for assessing skin lesions in atopic dermatitis]. Allergologiya. 2000;3:39–43.
9.  Kaliuzhna LD, Hrechanska LV. Pidkhid do rozrobky unifikovanoho klinichnoho protokolu z diahnostyky ta likuvannia atopichnoho dermatytu [Approach to the development of a unified clinical protocol for the diagnosis and treatment of atopic dermatitis]. Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii. 2016;3:44–46.
10.  Trelles MA, Alcolea JM, Martínez-Carpio PA. Transepidermal delivery of cosmeceuticals using radiofrequency and ultrasound: study of the penetration of a cosmetic gel in vivo by fluorescence microscopy. Glob. Dermatol. 2015;2(3):143–146.	
Publication of the article	«DERMATOLOGY AND VENEREOLOGY» №4(86), 2019 year, 18-22 pages,
 index UDK 616.5–001.1–021.5–08	
DOI	DOI: 10.33743/2308-1066-2019-4-18-22